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Some TFs induce DNA demethylation, such as nuclear factor-kappa B (Lichtenstein et al., 1994), Egr1/NGFI-A/Zif268/Krox-24 (Weaver et al., 2007), and the estrogen receptor that co-immunoprecipitates in the complex with DNMTs and the BER machinery (Metivier et al., 2008)

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However, if untreated, a vitamin B12 deficiency can lead to serious symptoms, including nerve damage or pernicious anaemia a condition when your body doesnt have enough B12 to make the red blood cells it needs

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