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10.1016/j.smrv.2021.101497 22 MarkovD

Out of 90 people in the study, 12 ended up needing a kidney transplant

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The primary endpoint was the presence of increased RCG, defined as, the presence of solids, thick liquids, or more than 1.5 mL/kg of clear liquids on gastric ultrasonography. Among the 124 subjects (median age, 56 years, 60% female), the prevalence of increased RGC was 56% (35 of 62) in subjects with GLP-1 RA use compared with 19% (12 of 62) in subjects not taking a GLP-1 RA drug

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Since co-treatment of UK-5099 and JMF4073 depleted dTTP pool and suppressed the growth of T315-Bcr-Abl-32D cells, we proposed that reducing GSH biosynthesis induces not only oxidative stress but also replication stress in tumor cells, which demands the synthesis of dTTP and dCTP for survival