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10.1016/s0928-4257(99)00123-0 129 SkorjanecS.DolovskiZ.KocmanI.BrcicL.Blagaic BobanA.BateljaL.et al (2009)

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In 1962, through analysis of the radioactivity incorporated into collagen using a tritiated version of the amino acid proline, Stone and Meister discovered that vitamin C is used as a co-substrate by peptidyl-prolyl hydroxylase, an enzyme that catalyzes the selective modification of proline to hydroxyproline

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