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This improvement is achieved by activating the Nrf2/HO-1 antioxidant pathway, inhibiting the NF-B-mediated inflammatory response, and blocking the TGF-/Smad3 fibrotic pathway as well as the Ripk1/Ripk3/Mlkl necroptosis pathway [231]

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10.1016/j.indcrop.2020.112331 27 DeriB.KanteevM.GoldfederM.LecinaD.GuallarV.AdirN.et al (2016)

Although antidepressants may benefit select patients, they are associated with adverse events in up to 32% of cases

Integr.Cancer Ther 2006;5(1):83-89

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