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This includes DNA damage that is leading to mutations and strand breaks, lipid peroxidation of cell membranes (disruption of fluidity and integrity), and denaturation of critical functional proteins, which collectively drive the cell towards apoptosis and contribute to the irreversible loss of beta-cell mass [86]

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By his own count, he was eating out five or six times a week: a biryani here, a long Sunday brunch there, late dinners with colleagues that stretched past ten

Voutilainen S, Morrow JD, Roberts LJ II, Alfthan G, Alho H, Nyyssnen K, and Salonen JT (1999)