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The commenter states that this change is essential to support recruitment, retention, and access to care in rural states like Iowa, as the current methodology does not accurately reflect the costs of operating clinical practices in low-GPCI areas and undermines health equity goals

It was first developed in 1991 as a derivative of Body Protection Compound, a peptide naturally found in human gastric juices [1, 2]

Concurrent astrocytic swelling indicated neuroinflammatory activation

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The Nrf2-independent effect of these inducers could result from their ability to activate additional transcription factors that are also able to increase GST expression, such as the pregnane-X-receptor (PXR), which in turn activates ARE signaling (reviewed in [32])