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Currently in Phase 3 clinical trials, retatrutide demonstrated unprecedented weight loss of up to 24.2% at 48 weeks in the Phase 2 trial published in the New England Journal of Medicine

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doi: 10.1038/s41591-022-02026-4 Summary Keywords obesity, molecular mechanism, semaglutide, liraglutide, weight loss Citation Tamayo-Trujillo R, Ruiz-Pozo VA, Cadena-Ullauri S, Guevara-Ramrez P, Paz-Cruz E, Zambrano-Villacres R, Simancas-Racines D and Zambrano AK (2024) Molecular mechanisms of semaglutide and liraglutide as a therapeutic option for obesity

Here's what you need to know: Low-dose naltrexone (LDN) is derived from standard naltrexone, typically used for opioid dependence

Res 127 , 486501 (2020)