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The thresholds reported in preclinical literature vary: PCB-157 : 10 g/kg to 1 mg/kg subcutaneously or intraperitoneally depending on the model

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Gastrointestinal symptoms, while frequent, typically improve within 48 weeks as the body adjusts to therapy

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333 The expression of miR-124 is low in UC patients, and in vitro experiments have shown that the upregulation of miR-124 can promote a decrease in proinflammatory cytokines, including IL-17 and IL-6, as well as the chemokine CCL2, which plays a role in alleviating UC