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Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

A 12-week study in which patients diagnosed with T2DM were treated with the DPPIV inhibitor, sitagliptin, revealed increased serum levels of PYY 1-36 and improvement of glucose and non-glucose dependent insulin secretion 71

In the UK, weight management is approached through a structured, evidence-based framework guided by NICE guidance, including NICE TA875 (semaglutide), NICE TA664 (liraglutide), and NICE CG189 (Obesity: identification, assessment and management)