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The CYP2E1 induced increases oxidative stress in the hepatocytes, activates fibrotic signals by enhancing proliferation of stellate cells and increases collagen type 1 protein [83]

Oral antioxidant therapy for prevention and treatment of preeclampsia: meta-analysis of randomized controlled trials

Extrahepatic manifestations of paediatric PFIC Extrahepatic symptoms are often observed in paediatric patients with PFIC subtypes if the affected gene is highly expressed in tissues other than the liver [55] (Fig

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However, results vary depending on baseline vitamin levels, metabolism, and overall health