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The calcium influx induced consequent to depolarizing GABA action places it squarely in the camp of being a trophic factor, although many of the aspects of its potential trophic action have not been well explored

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Accordingly, patient-reported complaints such as food tastes different, food is less enjoyable, or I no longer want to eat may reflect different points along this mediating chain: some may correspond to subjective value reappraisal under altered interoceptive states (5), whereas others may reflect reduced cue responsivity or motivational suppression arising from avoidance learning (5, 60)

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