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doi: 10.1177/0091270004273936 Summary Keywords dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, safety, discontinuation, dose-dependence Citation Meng Z, Yang M, Wen H, Zhou S, Xiong C and Wang Y (2023) A systematic review of the safety of tirzepatide-a new dual GLP1 and GIP agonist - is its safety profile acceptable

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They contain overlapping organisms, so combining all four may unnecessarily duplicate strains, increase cost and make side effects or benefits harder to interpret

Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 Diabetes Care 2011

Clinical evidence is thinner than youd expect