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By preventing nicotinamide methylation, the compound increases intracellular NAD+ availability, which in turn activates sirtuins and other NAD+-dependent enzymes critical for metabolic homeostasis

Pernicious anaemia , an autoimmune condition characterised by antibodies against intrinsic factor or gastric parietal cells, accounts for a significant proportion of cases in the UK

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if fatigue persists despite normal B vitamin levels, ask your doctor to check for other causes

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Biochem Mol Biol Int