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We emulated and benchmarked against two cardiovascular outcome trials (reference trials), SUSTAIN-6 (semaglutide versus placebo) and SURPASS-CVOT (tirzepatide versus dulaglutide) in a pair of cohort studies
Insulin secretion from oral glucose intake is greater than insulin secretion from IV glucose, termed the incretin effect [13]
Clinical studies have shown no major differences in clearance time across most patient groups with liver and kidney problems
Nooverlapping tirzepatide and semaglutide can cause excessive receptor stimulation and severe side effects
These combined effects limit fibrosis and contribute to the restoration of myocardial structural integrity, as evidenced by reductions in cardiac injury biomarkers such as CK, CK-MB, and LDH
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