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Although the equilibrium constant of the reaction favors the formation of SAH, under normal metabolic conditions, low intracellular concentrations of homocysteine and adenosine, SAH formed by transmethylation reactions is hydrolyzed into homocysteine and adenosine (Fig

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Zinc-dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer