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Diagnosis and Management Diagnosis is based on serum cobalamin assays (less than 200 pg/mL/ or 150pmol/L)

Unlike classic mastocytosis (where mast cells are overproduced), in MCAS the mast cell count is normal , but their behavior is dysregulated

Found in human plasma and tissues, GHK-Cu declines significantly with ageleading to slower healing, reduced collagen production, and visible aging of the skin

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10.1016/j.psyneuen.2015.12.019 67

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