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In the GH signaling, GH binding proteins are produced at the cell surface and play complex roles, including modulate the half-life of plasma GH and the binding of GH to GHR ( In most cases, the growth-promoting effects of GH depend on IGF1

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Numerous other studies, utilizing different animal models 35,36,37 or cell lines 38 , all agreed on the presence of mitochondrial problems especially with respect to TDP-43 pathology

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