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The importance of genetic factors in the development of ICI-associated irAEs was originally highlighted by genetic loss-of-function studies in mice (67, 68)

Growth Factors (IGF-1 and TGF): These hormones help stimulate the repair and regeneration of tissues

Glucagon Receptor Activation: Increased Energy Utilization: Activation of glucagon receptors elevates energy expenditure by enhancing hepatic glucose output and stimulating lipolysis, contributing to decreased adipose tissue

Vitamin D [4]

Please check with your personal physician before applying any of these suggestions

The first analyzed a large database of electronic health records