00:07:27 Vickie Danaher For example, oral semaglutide for obesity is also approved to reduce the risk of cardiovascular events, such as stroke or heart attacks, in patients with CV disease and obesity
Nausea, constipation, and reflux are common, especially during dose escalation, and going slower or staying lower feels like the obvious fix
Lancet 390(10103):16641675 Athauda D, Gulyani S, Kumar Karnati H et al (2019) Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the exenatide-PD trial
Common issues include nausea and gastrointestinal discomfort
Given the short timeframe of the GLP-1 demonstration, it is unlikely that there will be cost offsets from improved health due to increased GLP-1 use for obesity that can be documented
The anti-inflammatory mechanisms, including NF-kB suppression, TNF-alpha reduction, and macrophage polarization, are directly relevant to IBD pathology