10.1111/j.1601-0825.2010.01671.x Oral Dis
The first recombinant protein from helminths associated with the induction of T H 2 cells shown to operate by activating mast cells in an IgE-independent manner
In granulosa cells of women with endometriosis, elevated lipid peroxidation markers such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been observed, accompanied by decreased glutathione (GSH) and glutathione peroxidase 4 (GPx4), key inhibitors of ferroptosis ( Ferroptosis exerts a double-edged effect in endometriosis: while it damages ovarian granulosa cells, oocytes, and embryosdisrupting oocyte maturation, decreasing oocyte retrieval rates, and impairing embryonic developmentit also promotes ectopic lesion growth through downstream signaling pathways that enhance angiogenesis and inflammation ( Therapeutically, ferroptosis inducers can promote lipid ROS accumulation and endometriotic cell death but may exacerbate granulosa cell damage, while ferroptosis inhibitors protect granulosa cells against oxidative damage
A., Evans, A., Eid, N., Sadeghi-Nejad, H., & Ramasamy, R
Hin ti l Ph trng khoa Hi sc cp cu, Chuyn khoa Ni tng qut ti Bnh vin Si Gn
Crystal Structure of a Cobalt-Activated Diphtheria Toxin Repressor-DNA Complex Reveals a Metal-Binding SH3-like Domain