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It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61

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This vitamin exists in several forms, and because it contains a bit of a mineral called cobalt, the compounds within vitamin B12 are often referred to as cobalamins

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