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The prevalence and illness characteristics of DSM-5-defined mixed feature specifier in adults with major depressive disorder and bipolar disorder: Results from the International Mood Disorders Collaborative Project

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Consistent with the notion that GSH per se does not regulate mTORC1 and the ISR, depletion of intracellular GSH exacerbated the loss of mTORC1 signaling upon cystine deprivation, but was without observable effect in the presence of cystine (Fig