Ozempic suits type 2 diabetes management, requiring intensive, in-person medical interventions beyond telehealth's scope
While many PSMA-targeted ADCs have entered the clinical pipelineincluding SHR-4394, which carries an undisclosed payload and is currently recruiting patients for its first phase I clinical trial (NCT06783829)many have failed to advance beyond phase I/II clinical trials due to modest PSA response rates, inadequate survival benefit, and significant toxicity 80,81
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doi: 10.1038/nature07586 28 ShainAHYehIKovalyshynISriharanATalevichEGagnonAet al
About half (48%) of large firms with at least 200 workers say they have increased the mental health counseling resources available to their workers through an employee assistance program or third-party vendors such as Headspace or Lyra Health
Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class
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