Proc Natl Acad Sci U S A 96:10541058 van der Slot AJ, Zuurmond AM, van den Bogaerdt AJ, Ulrich MMW, Middelkoop E, Boers W, Ronday HK, DeGroot J, Huizinga TWJ, Bank RA (2004) Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon
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Curcumin-based nanoparticle formulations are being extensively investigated for possible therapeutics in many diseases
This conservative starting point allows assessment of individual response and tolerance before increasing if desired
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