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PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)

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NHPN-1010 treatment significantly upregulated GABA A R-1 subunit expression compared to saline intervention (Fig

At TrimRx, we prioritize this safety by ensuring every participant in our program is evaluated by a healthcare professional who can look at the big picture of their health