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From pioneering mass-market cigarette production to building some of the world's most recognized consumer brands, American cigarette manufacturers have influenced smoking habits, marketing strategies, packaging innovation, and international tobacco trade

Whole cigarettes (3 cigarettes from 3 different packages of the same variety) were extracted and analyzed in triplicate for the major commercial sensory cooling agents (menthol, WS-3, WS-23, WS-12, Frescolat MGA, Frescolat ML, Frescolat X-cool) by gas chromatography - mass spectrometry following published protocols (Supplementary file) 3

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