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It is surprising that in recent years, research has found that certain traditional Chinese medicine formulations or active ingredients can significantly improve the pathological conditions of patients with hepatitis B, and the combined use of traditional Chinese medicine preparations with antiviral drugs can achieve better therapeutic effects

The rationale is mechanistic non-overlap: rather than two compounds acting through the same pathway with redundant effects, BPC-157 and TB-500 engage distinct targets the former operating through nitric-oxide-pathway and VEGFR2 modulation, the latter through actin-cytoskeleton regulation

"The status quo for months now has been a compounder can create a copycat version of a branded drug, so long as they make some kind of minor tweak that they believe or they argue benefits specific patient groups," said TD Cowen analyst Michael Nedelcovych

Despite these promising findings, current evidence is preliminary, and the mechanistic basis for any comparative or synergistic advantages remains speculative

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