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hypoxia, wound fragments misadaptation, infection) tend to hamper this process resulting in scar formation or delayed healing, and probably induce VEGF formation by more than one mechanism (22)

Genetic Influences on Disc Degeneration IVD degeneration is a multifactorial, progressive disease, and recent evidence has also correlated disc degeneration with genetic mutations

Cell 36 (6), 19912005

Native IGF-1 is rapidly sequestered in circulation by IGF-binding proteins (IGFBPs 16), which extend its half-life but also restrict bioavailability

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