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MECHANISM CATEGORIES SAFETY Side effects GI: nausea, vomiting (titration-dependent) Injection-site reactions Hypoglycemia risk when combined with insulin Known interactions Insulin additive hypoglycemia risk Contraindications History of MTC or MEN2 (theoretical class effect) REGULATORY STATUS FDA Not yet FDA-approved as of 2026-05

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Briefly, adult fat bodies were dissected in 1 phosphate buffered saline (PBS), fixed 20 min in 4% paraformaldehyde at room temperature (RT), rinsed 5 in 1 PBS, then permeabilized for 30 min at RT in 1xPBS + 0.3% Triton X-100

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