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Participants receiving the highest dose of MariTide experienced an average weight loss of 21.6 percent of their baseline body weight at the end of 52 weeks, compared to a 2.4 percent weight reduction in the placebo group

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Although quality of life scores did not significantly change, the trial highlights clinically significant changes in functional mobility and shows direct vascular benefits from GLP-1 RAs [26]

To rule out the possibility that lean mass loss following BW reduction could have affected creatinine-based eGFR measurement, the muscle mass-independent endogenous filtration marker cystatin C was used to confirm the renal favorable effects attributed to tirzepatide [52]