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The HF diet significantly reduced the fishs exploratory drive, as evidenced by the HF group spending a longer period in the start arm compared to the control group

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PubMed Central Primary Mechanism: Folate-Methionine Cycle & AMPK Activation A concerted decrease was observed in the levels of 5-methyl-tetrahydrofolate (5Me-THF), the most abundant form of activated folate, and methionine, alongside elevated levels of homocysteine

MCI is the stage where oxidative stress starts to build up in the brain because of waning levels of the antioxidant glutathione, which happens with age