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So you need: Tryptophan availability BH4 (a key cofactor made via DHFR + folate) B6, B2, iron And low inflammation (so you dont divert tryptophan to the kynurenine pathway) MAOA: The Gene That Clears Serotonin MAOA (monoamine oxidase A) is an enzyme responsible for breaking down serotonin after its used

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Sickle cell vaso- occlusive crisis induces the release of circulating serum heat shock protein-70

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