d , Representative thermal denaturation curves of purified SLC33A1 in the presence of GSH with increasing concentrations (03,000 M)
Barry Conrad Yeah, so actually I have some questions while just while we're talking about that like the here were the OG form of urolithin A that we would be getting from our gut bacteria, because I'm actually working on a project with another fellow podcast guest right now we might be co authoring a book and it's all on short-term fatty acid production from the gut microbiome, but it's so basically the focus of it is is talking about postbiotics and metabolites of the gut microbiome and how how they service signaling molecules to the body which makes sense like basically they're creating these these signals to the body the body then reads as the state that the body is in like is it in a state of homeostasis is it in a state of stress like what what is happening but I'm really curious because I was reading the study last night where they were comparing taking mito pure to drinking pomegranate juice and in the study well first of all they they went and qualified whether or not people were naturally producers of urolithin A and like we were saying not everybody is so they realized some people didn't produce it at all some some people didn't have like baseline didn't have any in their system some did some only like a few had higher amount and then when they gave them like pomegranate juice for example which is that precursor then some people still didn't create it some people made like a little bit and then you know some made a lot but when they compared it to mito pure mito pure led to like a much more higher level of urolithin A in the participants and presumably all the participants compared to you know the producers who had to produce it on their own from the pomegranate juice but what I'm curious about is they were saying that like the natural the people were producing it naturally the curve was that there was like you know a smaller amount after like I think like four or six hours and then after 24 hours there was more compared to taking mito pure there was actually a bolus right in the beginning and then it would go down after 24 hours but then but it was still way more in their system than compared to creating it normally from the pomegranate juice but so my question is do we know how much like physiologically with what it's doing urolithin A in our body do we know how much we actually need to experience the benefits because I know you're about to go into you know what it actually does with our mitochondria and stuff so like is more even better or is it just that if you get that signal at all that's what works and is it possible that you could have like too much like could you oversaturate your system Speaker 3 So what we know, you know, so there hasn't really been like a defined sort of like threshold of like, this is how much your olefinae should be in your bloodstream at all times, right
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