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this definition of CB has been predictive of more severe symptoms and high-risk patient groups [11]

Genotyping Gpx4 Tg/+ mice were characterized using PCR primers: 5-CGTGGAACTGTGAGCTTTGTG-3 and 5- AAGGATCACAGAGCTGAGGCTG-3, yielding a 300 bp DNA fragment upon overexpression of GPX4

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This finding suggests that the insertion of the octanoyl group into cavity II not only contributes to the binding of the ligand, but also helps to orient the N-terminus of ghrelin to cavity I, which is critical in receptor activation

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