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The global cancer statistics for the year 2020 show that approximately 2.3 million new cases of breast cancer, accounting for 11.7% of all female cancer diagnoses, are identified worldwide ( In their study, Martin et al

Mitochondrial ablation in senescent cells suppressed CCF formation and activates p53, suggesting that mitochondria-dependent formation of H2A.X and CCF dampens nuclear DNA damage signaling and p53 activity in the tissue (Miller et al., 2025)

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