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"Animal models do not always translate into humans
Sardinia MF, Hanesworth JM, Krebs LT, Harding JW
After that, GSH (10 mM) was added to the solution of NSBSO with incubation at 37 C for 24 h to trigger the GSH response, resulting in poor fluidity of the solution
Several barriers must be overcome when developing orally administered peptides with a molecular weight above 1,000 Da, including enzymatic degradation in the GI tract, pH-induced conformational changes, limited permeability of the intestinal membrane, and variable GI tract absorption rates [2, 3, 42, 43]