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Damage to the cell membrane generates arachidonic acid, followed by the formation of aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal

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However, existing medical methods (e.g., antidepressants) have a response rate of only 50% in MDD patients (6), and early clinical symptoms of depression (e.g., anhedonia, sleep disturbance) are often ignored, further worsening health outcomes