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Secondary outcomes included absolute change in body weight and weight circumference from 36 to 88 weeks, the percentage of adults achieving at least a 5%, 10%, 15%, 20% or 25% weight loss from baseline to 88 weeks and the percentage of adults that maintained at least 80% of the body weight they lost during the open-label period

Constipation Some people experience slower bowel movements or constipation instead of diarrhea [20][41]

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DPP-4 enzyme rapidly degrades active GLP-1, reducing its circulating half-life to just 2-3 minutes

It is important to be clear that GLP-1 medicines like this are not stimulants: unlike caffeine, synephrine, or the withdrawn drug sibutramine, they do not increase heart rate by driving the sympathetic nervous system

Take 2 capsules daily, preferably before a meal