Both have stress-modulating properties
Dotted line suggests plausible asymptotic relationship with exogenous GLP-1 medications that produce concentrations that are 1000x higher (ng/ml)
Exhibit 6 The states we spoke with agreed that there is value in examining whether their Medicaid marketing requirements conflict with their broader goals for aligned enrollment of dual eligible individuals
While one person might experience significant nausea with semaglutide, they might tolerate tirzepatide better, or vice-versa, due to subtle differences in their pharmacological effects and how their body metabolizes them
Pathway Two: GHS-R Agonists (Ipamorelin, GHRP-2, GHRP-6, MK-677) These compounds act on the ghrelin receptor (GHS-R1a), a separate pathway from GHRH
(2017) Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species