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Inga Murawski for the generation of the BioRender figures in this manuscript Funding This work was supported by the Canadian Institutes for Health Research Project Grants 168836 and 162273)

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If necessary, the dose may be increased to 1 mg or 2 mg weekly after at least 4 weeks at each dose level

Willard FS, Douros JD, Gabe MBN, Showalter AD, Wainscott DB, Suter TM, et al