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PMC 2826423

[7] Hydroxocobalamin was first isolated in 1949

TL;DR Summary: Industry standard dosing ranges from 600-1,200 mg per session, typically administered 1-3 times weekly for 4-8 weeks, though these protocols lack peer-reviewed evidence support

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Additionally, the detection of these active metabolites means that when the therapeutic activity of 7,8-DHF is evaluated, the effects of the metabolites may also need to be considered

Keywords Carrageenan Model