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Cardiovascular Benefits: The Most Robust Evidence Base Let me start with what matters most to a cardiologist

However, it is known that in some cases, peripheral substances can influence the brain without crossing the BBB

These systemic, functional effects underscore that GLP-1 RAs can enhance healthspan independently of classical biological aging endpoints and reinforce their emerging role as versatile gerotherapeutics

However, anyone considering a GLP-1 patch should discuss it with a healthcare professional to understand whether its safe for their specific health needs

This reduced peripheral circulation helps explain why extremities, in particular, feel cold, as theyre receiving less warming blood flow, and our body prioritises core organs