The disadvantages are slightly lower efficacy and the requirement for daily use rather than weekly injections. GLP-1 medications work by suppressing appetite
This dysfunctional state creates a local and systemic inflammatory milieu, contributing directly to the development of systemic insulin resistance [1, 6]
For example, since 2018, spending on Ozempic increased 34 times while spending on Trulicity increased 1.7 times, as shown in the graph below
That said, your provider should still establish a baseline with fasting glucose and HbA1c before starting, and monitor periodically throughout treatment
The alternative, use-it-or-lose-it policies, encourages employees to take time off but creates end-of-year pressure and can result in operational disruption
They genuinely care about you and whatever brought you into the office they want to make sure the experience is a pleasant one