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There is evidence showing that GLP-1RAs can reduce the expression of cell apoptotic markers Bcl-2-associated x (Bax) and caspase-3 while upregulating Bcl-2 [99, 100], as well as protecting against lipotoxic stress via phosphoinositide 3-kinase (PI3K)/Akt/forkhead box proteins O1 (FoxO1) pathway [101]

In other cases, symptoms continue or worsen

Nature (2021) 592:73746

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GLP-1 and GIP receptors affect appetite, insulin sensitivity, and satiety

Clinical evidence unveils the translational potential of GLP-1RAs GLP-1RAs notably lower the risk of cirrhosis and HCC in individuals with type 2 diabetes and liver conditions