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A compound approved by PCAC today could not legally be dispensed by compounding pharmacies until late 2027 or 2028 at the earliest under standard rulemaking timelines

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The activation of the TGF-/Smad pathway contributes to pEMT, myofibroblast activation, ECM synthesis and deposition, podocyte depletion, and mesangial expansion, which are essential steps in the progression of kidney fibrosis [73]

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Three mathematical models were used to analyze the obtained results: zero order [46], Higuchi [47,48] and KorsmeyerPeppas [49,50]