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Once in circulation, GLP-1 is rapidly degraded by DPP-4, which cleaves the active hormone to form GLP-1(9-36) with significantly reduced insulinotropic activity

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Special considerations for specific populations Retatrutide fatigue in people with type 2 diabetes The Lancet published data from a phase 2 trial specifically examining retatrutide in people with type 2 diabetes (Rosenstock et al., 2023)