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Discovery of selective P2Y(6)R antagonists with high affinity and in vivo efficacy for inflammatory disease therapy
Only adults who were prescribed a dosage approved for glycemic control were included
Retatrutide achieved up to 24.2% body weight reduction over 48 weeks in the Phase 2 trial published in the New England Journal of Medicine , which involved adults with obesity but without diabetes
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It functions as a ghrelin agonist and is often found in combination with other peptides
Of note, the mean basal insulin dose at the study endpoint (week 52) was 48.8 U with insulin degludec in the SURPASS-3 trial and 43.5 U with insulin glargine in the SURPASS-4 trial [20, 21]
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