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Tolerability, Side Effects, and Adherence Rates Gastrointestinal side effects occur with both oral and injectable semaglutide, typically appearing in the first 1 to 2 weeks as your body adapts

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However, nausea may continue into your next dayeveryone responds differently

Common signs and symptoms include: Nausea and Vomiting: Individuals with gastroparesis often experience frequent and persistent nausea, which may be accompanied by vomiting, especially after eating

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