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Normalization of circadian rhythm stabilizes melatonin secretion, improving sleep quality and nighttime regeneration

Data is largely limited to laboratory and preclinical models, with minimal validated human research available

The pituitary-adrenal axis

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The PKA and EPAC2 pathways are triggered by both receptors'activation of adenylate cyclase, which raises intracellular cAMP and causes insulin synthesis and release, cellular proliferation, and antiapoptotic effects

It also acts through ERK1/2, which supports endothelial tube formation