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The toxicity of metal-based NPs depends on their physicochemical properties, such as chemical composition, size, shape, and surface chemistry (Figure 1) (Wu and Tang, 2018)

doi: 10.1016/j.beem.2004.04.001

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The stress-inducible transcription factor NUPR1 targets lipocalin-2 (LCN2), an iron-transporting protein that, along with FPN1, releases Fe 2+ into the extracellular space to suppress ferroptosis [23]

Multiple studies have demonstrated that MSC-Exos attenuate ferroptosis in chondrocytes by targeting key molecular axes

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